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The critical nature of the expression of cell adhesion components, proteinases, and coagulation mechanisms of impor- tance in invasion and metastasis has already been discussed.

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MeijermanI,BeijnenJH,SchellensJHM(2006)Oncologist11:742 75. For such patients, the use of more intensity levels or optimized weightings of the segments might result in a further increase in dose homogeneity.

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