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The induction of caveolin-1 suppresses anchorage independent growth [Engelman et al. The goals of closure are obliteration of the cuff's dead space back to the peritoneum and approximation of the cut edges of the vagina to afford healing and minimize postoperative granulation tissue. Other congenital risk factors include mutation of the Leiden factor, which is responsible for protein C-activated resistance. Cytology Cytological examination of testicular tissue comple- ments the histological evaluation and should be routinely performed with diagnostic biopsy.

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