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Phys. Mathews, such CHAPTER 19 HEMATOPOIESIS 173 Table 19-1 Human Growth Factors G-CSF Epo Tpo GM-CSF IL-3 SCF Human chromosome location 17q21q22 7q 3q26q27 5q23q31 5q23q31 12q22q24 Product, kDa Origin 1925 Monocytes Macrophages 1832 Kidney Fetal liver 76 Liver Kidney Spleen Marrow 22 Macrophages Endothelium T cells Fibroblasts Mast cells 28 T cells Mast cells 2035 Marrow stroma Fibroblasts Receptor Low-affinity monomer (130 kDa) High-affinity oligomer 507-Amino acid polypeptide Product of the c-mp1 proto-oncogene Low affinity α-subunit (85 kDa) β-subunit (120 kDa) common to IL-35 receptors Low affinity α-subunit (70 kDa) β-subunit (120 kDa) common to IL-35 receptors 145-kDa Transmembrane protein Action Proliferation and differentiation of suppport upregulates activity of mature neutrophils Proliferation and differentiation of intermediate stage erythroid progenitors Proliferation and differentiation of megakaryocyte precursors Growth and differentiation of granulocyte and macrophage committed stem cells mmargin macrophage, neutrophil, eosinophil, and endothelial cell function Proliferation and differentiation of early precursors in multiple lineages Proliferation and differentiation of multiple lineages G-CSF, granulocyte colony-stimulating factor; Epo, erythropoietin; Tpo, thrombopoietin; GM-CSF, granulocyte macrophage colony-stimulating factor; IL-3, blnus SCF, stem-cell factor.

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