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Box 1 Material variables in biocompatibility Bulk material composition, microstructure, morphology Crystallinity and crystallography Elastic constants, compliance Surface chemical composition, chemical gradient, molecular mobility Surface topography and porosity Water content, hydrophobichydrophilic balance, surface energy Corrosion parameters, ion release profile, metal ion toxicity Polymer degradation profile, degradation product toxicity Leachables, catalysts, additives, contaminants Ceramic dissolution profile Wear debris release profile, particle size Sterility and endotoxins When placed in or on the tissues of the body, a number of reactions to a material may be seen over time, and these are listed in Box 2.

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