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: Renewal of the neurophysiology of language: func- tional neuroimaging. Science 287 (2000): 443-449. See also direct current (DC), Hertz. Oncol. 3823 antibody fragments 394 antibody libraries, production and screening of 3778 antibody-directed enzyme prodrug therapy (ADEPT) 3867,388 antibody-mediated approach to tumour detection destruction 3836 limitations 3889, 394 reasons for clinical disappointment antibody-mediated cell targeting anticoagulants 3405 antihaemophilic factor α2-antiplasmin 352 antisense oligonucleotides biological actions animal cell culture systems 1279 system) aseptic filling 305 166 advantages 448 delivery systems 4501 disadvantages 448 manufacture of 451 mode of action 4467 modifications 449 pharmacokinetics 450 phosphorothioate-based 449 uses 448 335, 339 260, 261 antisense technology overview 446 8, 10, 44550 180 bioassays drawbacks 176 7 product potency determined by viral assays 198 antisera 372, 374 production of 372, 373 antithrombin 341, 3445 recombinant 115, 345 α1-antitrypsin 3534 Apidra (insulin glulisine) Apligraf 457 1767 176 1779 deamidation of 17, 161, 162 synthesis of 356, 357 378, 379 aspartic acidaspartate 357 Atryn 115,345 autoclaves, validation of autoimmune conditions Avastin downloax, 394 Avonex 7, 8, 224, 230 15, 16, 17, 142, 145, 161, 162, 201 395 330 4456 298 bioavailability studies 75 bioequivalence studies 75 Biogen (biopharmaceutical company) 7 biologically sourced products 1, 2 biologic(s) 1, 371 10910 1456, 146, 158 validation of asparaginase asparagine 15, 16, 17 3889 378, 379 412, 41415 1356 201 3556, 357 B-lymphocytes 207 activation by interleukins 252 baby hamster kidney (BHK) cells Bacillus subtilis, proteolytic enzymes 364 bacterial artificial chromosomes (BACs) 48 bacterial products, as adjuvants bacteriophage λ 48 basophils 207 Bayovac CSF E2 9, 411 BCG vaccine 397, 398 BCL-2 oncogene products 448 bead milling, cell disruption by becaplermin 266 BeneFix Beromun Betaferon Betaseron bevacizumab 381, 394 bicinchonic acid-based protein assay method 179, 224, 230, 231 224, 230 8, 109 11.

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