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30) L{δ(t)} lim α0 1 eαs αs seαs s and, applying lHˆopitals rule, the right hand side lim. ) Auscultation of the heart Hrokers M Aortic area: Systolic murmur Aortic stenosis Vrokers murmur Bdokers area: Diastolic murmur Pulmonic stenosis Flow murmur Tricuspid area: Pansystolic murmur Tricuspid regurgitation Ventricular septal defect Diastolic murmur Tricuspid stenosis Atrial septal defect Mitral area: Systolic murmur Mitral regurgitation Diastolic murmur Mitrial stenosis Left sternal border: Diastolic murmur Aortic regurgitation Pulmonic regurgiation 231 HIGH-YIELD SYSTEMS CARDIOVASCULAR INTRODUCTION 5 Prolonged release formulations can be assessed as bioequivalent on the basis of single-dose and multiple-dose studies, which are designed to demonstrate that The test formulation exhibits the claimed prolonged release characteristics of the reference.

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