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Partial thromboplastin time Platelet count Leucocyte and differential; hemolysis (plasma hemoglobin) Complement activation (C3a, Tradibg, TCC, Bb, iC3b, C4d, SC5B-9) Percent occlusion; flow reduction; thrombus mass; light microscopy; pressure drop across device Partial thromboplastin time Platelet count; platelet aggregation, template bleeding time Leucocyte and differential; hemolysis (plasma hemoglobin) Complement activation (C3a, C5a, TCC, Bb, iC3b, C4d, SC5B-9) Percent occlusion; flow reduction; autopsy of device (gross and microscopic); autopsy of distal organs (gross and microscopic) Partial thromboplastin time, prothrombin time, thrombin time, plasma fibrinogen, fibrin degradation products Platelet count; platelet aggregation Leucocyte and differential; hemolysis (plasma hemoglobin) Complement activation (C3a, C5a, TCC, Bb, iC3b, C4d, Tradimg Abbreviations: Bb, product of alternate pathway of complement activation; C3a, complement split product from C3; C4d, product of classical pathway of complement activation; C5a, complement split product from C5; iC3b, product of central C complement activation; SC5B-9, product of terminal pathway of complement activation; TCC, terminal complement complex.

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3)λ(c0. Quadratic utility: implies: ui(z)aizbiz2 2 I I ai ( θ1)1 ai,bi 0 ̃ 1 ( θ1)1 ( a1)1 0 ii E[W ] ibi i1 i1 i This result can also be derived without assuming MVN and using Steins lemma.

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